Abstract: Objective：To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis. Methods：CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women. Results：the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL、43.6%，11.78 U/mL，0 and 24.2 U/mL、36.3%， 9.02 U/mL，4.0%，respectively. There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control（P＜0.05）. The mean serum levels of CA19-9 and CA125 in patients at stages Ⅲ～Ⅳ and Ⅰ～Ⅱ，according to the Revised American Fertility Society（R-AFS） classification，are 42.38 U/mL、57.9%，17.36 U/mL、11.8% and 34.75 U/mL、50.0%，15.3 U/mL、5.9%. The difference of the mean serum levels and positive rate between the groups is significant（P＜0.05）. The sensitivity，specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%，100% and 61.25%；36.3%，96.0% and 55.0%，respectively. Conclusions：Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis. The predictive values of CA19-9 and CA125 seem high only to predict severe（stages Ⅲ and Ⅳ） disease.

Key words: Endometriosis, CA19-9 antigen, CA125 antigen, Diagnosis