Abstract: As a member of transforming growth factor-β superfamily， growth differentiation factor-9（GDF-9） is an important regulatory factor on development and functions of follicles. GDF-9 regulates the formation of dominant follicle and process of oocyte maturation. Polycystic ovary syndrome（PCOS） and premature ovarian failure （POF） are both common reproductive endocrine diseases in women of child-bearing age， but there is no effective treatment so far. This article summarizes structure function and mechanism of action of GDF-9 gene. In addition， the relationship between GDF-9 and ovary diseases is reviewed.

Key words: Transforming growth factor beta, Polycystic ovary syndrome, Ovarian failure, premature, Oocytes, Genes