Abstract: Ovarian cancer is one of the most common and lethal gynecological malignancy，leading cause of cancer deaths among women. It has been the main tumor that threatens the life and the health of women. The early clinical symptoms of ovarian cancer conceal，70% of the patients attending is late，the 5-year survival rate was only 30%，and 5 year's survival rate of early ovarian cancer was 90%. Now it is urgent and necessary to search new tumor markers with high specificity and sensitivity that are useful for early diagnosis of ovarian cancer and for the improvement of survival rate. Carbohydrate antigen，human epididymis 4（HE4），NECTIN4，lysophosphatidic acid（LPA），trkA and microRNA play a role in ovarian cancer diagnosis，of which CA125 is most widely used in clinical diagnosis. Micro RNAs as new tumor markers can improve the diagnosis methods of ovarian cancer.

Key words: Ovarian neoplasms, Early diagnosis, Tumor markers, biological, CA-125 antigen, MicroRNAs