Abstract: The tumor microenvironment is a tumor cell， stromal cells， cytokines， immune cells such as tumor constitute the environment of local pathology， which is tissue hypoxia， acidosis， interstitial high pressure and so on. In tumor microenvironment in a large number of growth factors， proteolytic enzymes and the immune inflammatory response which interact on the tumor cell surface， play an important impact on cell proliferation，metastasis，differentiation. Early symptoms of ovarian cancer because of its atypical metastatic quickly， so the prognosis is poor， has become one of the serious threat to women′s health tumor. In this paper the tumor microenvironment and the malignant behavior of ovarian cancer combined with each other， are reviewed.

Key words: Ovarian neoplasms, Chemokines, Cytokines, Extracellular matrix, Tumor microenvironment