Present Research of SHBG Gene Polymorphism

Journal of International Obstetrics and Gynecology ›› 2012, Vol. 39 ›› Issue (4): 384-387.

• 综述 • Previous Articles Next Articles

Present Research of SHBG Gene Polymorphism

XIA Yan-jie， WANG Yong

Jiangsu Key Laboratory of Molecular technology， Medical School of Nanjing University， Nanjing 210093， China

Received:1900-01-01 Revised:1900-01-01 Published:2012-08-15 Online:2012-08-15
Contact: WANG Yong

Abstract

Abstract: Sex hormone-binding globulin is a kind of hormone carrier protein mainly synthesized in the liver， which functions by adjusting the concentration of sex hormones. Up to now， many diseases such as Type Ⅱ diabetes （T2DM）， cardiovascular disease， cancer and polycystic ovary syndrome （PCOS） have been found related with serum SHBG. There is considerable heterogeneity in the results of these studies indicating the multiplicity of the factors influencing SHBG variation. However， the most important of evidences suggest that some common genetic variants of SHBG may influence SHBG levels.

Key words: Sex hormone-binding globulin, Polymorphism, genetic, Genes, Biology, Polycystic ovary syndrome

XIA Yan-jie;WANG Yong. Present Research of SHBG Gene Polymorphism[J]. Journal of International Obstetrics and Gynecology, 2012, 39(4): 384-387.

[1]	CAO Xiu-rong, ZHOU Wen-bai, FAN Xiang, WANG Yi-fei, ZHU Peng-feng. Single-Cell RNA Sequencing Analysis of the Angiogenesis Mechanism in Endometriosis [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 199-205.
[2]	XU Shu-ying, XU Hai-peng, WANG Li-na, ZHANG Yang. Relationship between Zinc and Polycystic Ovary Syndrome [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 217-221.
[3]	YAN Hui-bo, ZHANG Lin. Analysis of the Disease Burden and Projections of Polycystic Ovary Syndrome in China and Globally from 1990 to 2021 [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 228-233.
[4]	ZHANG Yun-feng, ZHANG Wan-yue, LU Yue, WANG Yang-yang, JING Jia-yu, MU Jing-yi, WANG Yue. Research Progress of ARID1A and PIK3CA Mutations in Malignant Transformation of Ovarian Endometriosis [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 19-22.
[5]	JIA Yan-feng, WU Zhen-zhen, WANG Wei-hong, WANG Yue-yuan, LI Juan. A Case of Primary Ovarian Adenosquamous Carcinoma [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 32-36.
[6]	ZHANG Dong, WANG Zheng, LI Kai, BIAN Wen-li, GAO Zhi-hua. A Case of Severe Spontaneous Ovarian Hyperstimulation Syndrome in Non-Pregnancy [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 79-83.
[7]	ZHANG Wen, LIU Hui-qiang. The Role of SOCS1 and Exosomal MicroRNA in the Pathogenesis of Preeclampsia [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 94-98.
[8]	WANG Yi-dan, WANG Yong-hong. The Role of the Transforming Growth Factor-β Superfamily in the Pathogenesis of Preeclampsia [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 99-104.
[9]	QIU Wan-ning, WEI Yuan. Advances in the Etiological Research of Discordant Anomalies in Monozygotic Twins Pregnancy [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 607-610.
[10]	FAN Bo-yang, HU Li-yan. Research Advancements on the Pathogenesis and Prediction Approaches of Twin Pregnancies Complicated with Preeclampsia [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 611-615.
[11]	HU Die, REN Jia-jie, LIU Jia-ning, FENG Xiao-ling. Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 684-691.
[12]	LI Dong-nan, XIANG Rong, WANG Hai-yang, SUN Miao. Regulatory Mechanism of Ovarian Granulosa Cell Apoptosis in Polycystic Ovary Syndrome with Progress in Traditional Chinese Medicine [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 692-697.
[13]	LI Chen-xi, FAN Meng-xiao, WU Lin-ling, DOU Zhen, JIA Jia, SUN Ya-xuan. Advances in Research on Neuroendocrine Disorders Induced by Hyperandrogenism in Polycystic Ovary Syndrome [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 698-702.
[14]	CHEN Zhi-wei, LIU Lin. A Case of Ovarian Malignant Tumor with SMARCA4 Gene Deletion [J]. Journal of International Obstetrics and Gynecology, 2024, 51(5): 584-587.
[15]	TONG Fei, HUANG Wei-tong, LIU Kai-min, ZHOU Shuo-an, LU Xiu-hua. Analysis of Small Supernumerary Marker Chromosomes Repeated in Two Fragments of 15q in A Fetal Amniotic Fluid Case [J]. Journal of International Obstetrics and Gynecology, 2024, 51(4): 473-476.

Present Research of SHBG Gene Polymorphism

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments