Abstract: Hyperglycosylated hCG is a subtype of hCG produced by trophoblast cells in early pregnancy and tumor cells. Hyperglycosylated hCG promotes trophoblast invasion in choriocarcinoma，growth of cytotrophoblast cells and placental implantation in pregnancy. Hyperglycosylated hCG is a reliable bio-marker of gestational trophoblastic diseases and a valuable marker for Down syndrome screen，hypertensive disorder prediction in pregnancy and gestational trophoblastic tumor management.

Key words: Glycosylation, Chorionic gonadotropin, Trophoblastic neoplasms, Perinatal care