Abstract: Angiogenic factors and anti-angiogenic factors have been studied in many areas. Now，they have become a hot spot in the Pathological obstetric，many research are on the preeclampsia in maternal plasma，but the role of stillbirth in them is still ralely repored. This paper mainly discusses the clinical etiology of stillbirth，the significance of PIGF、 sVEGFR-1、sEng change and the reasons for stillbirth of amniotic fluid and maternal serum of endothelial growth factor receptor-1、placental growth factor and soluble endoglin sEng concentration. We make a detailed study of the relationship between changes of anti-angiogenic and Anti-angiogenic factor and the occurrence of stillbirth，open up new ideas for the etiology and pathogenesis of stillbirth.

Key words: Fetal death, Angiogenesis inducing agents, Vascular endothelial growth factor receptor-1, Pathology