Journal of International Obstetrics and Gynecology

Journal of International Obstetrics and Gynecology ›› 2014, Vol. 41 ›› Issue (6): 663-666.

• 论著 • Previous Articles     Next Articles

Correlation of DNA Methyctransferase 1 Gene Polymorphisms and Passive Smoking with Cervical Cancer

WANG Ling，JIN Ping，SONG Yi，SUN Yuan-peng   

  1. The First Hospital of Lanzhou University, Lanzhou 730000, China（WANG Ling）；Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital of Southern Medical University, Shenzhen 518000, China（JIN Ping）；The First Clinical Medical College（SONG Yi）, School of Basic Medical Sciences（SUN Yuan-peng）, Lanzhou University, Lanzhou 730000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15
  • Contact: JIN Ping

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Abstract: Objective：To evaluate the possible relationship between DNA methyctransferase 1（DNMT1）gene polymorphisms and passive smoking with cervical cancer in Han population of Gansu province，China． Methods：A case-control study，DNMT1 gene polymorphism were detected by PCR and gene sequencing method in 100 patients of cervical cancer in Gansu province and 100 healthy controls. The relationship between different genotypes，passive smoking conditions and the risk of cervical cancer was analyzed． Results：Passive smoking has increased risk of developing cervical cancer by 2.705 times（P＜0.05）；the frequency of C allele of rs16999593 in cervical cancer patients was significantly higher than that in control group（P＜0.05）．Conclusions：These findings suggest that DNMT 1 gene polymorphism and passive smoking increased risk of cervical cancer.

Key words: DNA（Cytosine-5-）-methyltransferase, Alleles, Sequence analysis, DNA, Tobacco smoke pollution, Uterine cervical neoplasms