Abstract: In recent years, the long non-coding RNA（lncRNA） were thought to be the "noise" of genome transcription obtained the widespread attention. lncRNAs are broadly defined as RNA molecules greater than 200 nt in length and do not encode proteins by themselves. But they have a close connection with the bioinformatics function, involving in epigenetic regulation, cell cycle, mRNA degradation , tumour drug resistance and other aspects. They play a critical role in the formation , development, erosion and metastasis of tumor, as well as diagnosis and prognosis of disease. At the same time, lncRNAs have certain connections with the hormones and the P53 signaling pathway. With the aid of various molecular biology methods, we continue to parse the function and molecular regulation mechanism of lncRNAs, and significant differences of lncRNA expression have been found between tumor cells and the corresponding normal tissue. Moreover, abnormal expression of lncRNA is closely related to a variety of malignant disease. The correlation between lncRNA and gynecological tumors provides a new perspective for the diagnosis and treatment of gynecological malignant tumor.

Key words: RNA, Uterine cervical neoplasms, Ovarian neoplasms, Endometrial neoplasms, Epigenesis, genetic, p53