Abstract: Cervical cancer seriously threat the health of women，and human papillomavirus is closely related with cervical lesions and cervical cancer. People are striving to find the mechanism of the occurrence and development of cervical cancer.Recent years，studies indicate that a multi-functional nucleoprotein， death domain associated protein （Daxx） has been found.Daxx may interact with proteins in cells or viral proteins，and be involved in cell activities such as regulating cell apoptosis， transcription regulating or antiviral. It plays different roles in physiologically or pathologically through different pathways. Research the function and mechanism of Daxx can expand our knowledge of the origin and development mechanism of cervical cancer，which is helpful to find new methods of prevention and treatment. This paper reviews the biological characteristics and the current states of Daxx，and research progress on Daxx in cervical lesions.

Key words: Death domain associated protein, Uterine cervical diseases, Papillomaviridae, Apoptosis, Transcription factors