Abstract: High-risk human papillomavirus (hrHPV) infection is the main cause of cervical intraepithelial neoplasia and invasive cervical cancer and closely related with the occurrence of cervical squamous cell carcinoma and most cervical adenocarcinoma. However, researchers have found that cervical cancer with negative hrHPV test results still exists, and about 10% of the carcinogenesis of cervical adenocarcinoma has no relationship with HPV infection. These adenocarcinoma mainly include: minimal deviation adenocarcinoma which belongs to gastric-type mucinous adenocarcinoma, clear cell carcinoma, mesonephric adenocarcinoma and papillary serous carcinoma. These unusual types of cervical adenocarcinoma were often misdiagnosed due to lack of specific clinical manifestations and difficulty in screening and diagnosis, so that most patients missed the best time of treatment and the prognosis was poor. This review summarizes the advances in the etiology, clinical manifestations, diagnosis, treatment and prognosis of cervical cancer associated with non-HPV infection by reviewing the literature.

Key words: Adenocarcinoma, Uterine cervical neoplasms, Diagnosis, Therapy, Prognosis