Abstract: Cervical intraepithelial neoplasia (CIN) is a precursor lesion for cervical cancer. The occurrence and progression of CIN is a multi-factor, multi-level process. Numerous studies have confirmed that high-risk HPV persistent infection is an important tumorigenesis cause of CIN and cervical cancer and is closely associated with the development of cervical cancer. With advances in molecular biology and the development of sequencing technology, the association of low genital tract microbiota with human papillomavirus (HPV) in the development of cervical intraepithelial neoplasia and cervical cancer is gradually being recognized. It has become a popular study to find and explore the prognostic biomarkers of CIN to predict the progression of CIN. This paper reviews the etiology, the influencing factors, and the markers associated with the progression of CIN, in order to properly predict the development of CIN, regulate the diversion and cervical intraepithelial management.

Key words: Cervical intraepithelial neoplasia, Papillomaviridae, Biological markers, Uterine cervical neoplasms