Abstract: With the rapid development of cardiac surgery, more and more patients with heart valve disease can improve cardiac function and life quality through heart valve replacement. However, life-long anticoagulant therapy is required after mechanical heart valve replacement, and it is particularly important during pregnancy. Although mechanical heart valve replacement is associated with high-risk pregnancies, there is a lack of uniformity in the management of cardiac mechanical valve replacement. Individualized treatment is generally emphasizes. Anticoagulation during pregnancy after mechanical heart valve replacement is controversial. Warfarin can prevent the formation of maternal thrombus during pregnancy, but warfarin can affect the development of the fetus through the placenta. Heparin can not affect the development of the fetus through the placenta, but poorly monitor the convenience and prevent thrombosis. The anti-platelet drugs and the use of new drugs have not been further study. We reviews the choice of anticoagulants and maternal fetal outcomes in recent years in order to better serve the clinic.

Key words:  Heart valve prosthesis implantation, Pregnancy, Pregnant women, Warfarin, Anticoagulants, Heparin