Abstract: Objective：To explore the prognostic factors of stage ⅢC or Ⅳ epithelial ovarian cancer and to provide data support for clinical diagnosis and treatment. Methods：Clinical date of patients with stage ⅢC or Ⅳ epithelial ovarian cancer in our hospital were analyzed retrospectively, including age, clinical stage, histopathological type and grade, size of postoperative residual disease and number of postoperative chemotherapy cycles. The effects of these factors on the prognosis of patients with stage ⅢC or Ⅳ epithelial ovarian cancer were evaluated. Results：Univariate analysis showed that age, size of postoperative residual disease and number of postoperative chemotherapy cycles were closely related to the prognosis of the patients. Clinical stage, histopathological type and grade were not statistically significant. Multivariate analysis using COX regression model showed that age ≥50 (RR=0.493, 95%CI: 0.308-0.790), size of postoperative residual disease ≥1 cm (RR=2.527, 95%CI: 1.585-4.028) and number of postoperative chemotherapy cycles ＜6 (RR=2.294, 95%CI: 1.464-3.593) were independent risk factors for prognosis in patients with stage ⅢC or Ⅳ epithelial ovarian cancer. Conclusions： For patients with stage ⅢC or Ⅳ epithelial ovarian cancer, they would have worse prognosis if the  patient is the older or the size of postoperative residual disease is larger or the number of postoperative chemotherapy cycles is less.

Key words: Ovarian neoplasms, Neoplasms, glandular and epithelial, Prognosis, Prognostic factors