Abstract: Objective：To explore the influencing factors of parametrial involvement (PI) in the conization specimens of early-stage cervical cancer. Methods: A retrospective analysis of 200 patients with cervical carcinoma stage Ia2-Ib1 who were diagnosed as cervical cancer through cervical conization, and who had the operation of radical hysterectomy (RH) and pelvic lymphoadenectomy during their visit to Dalian Women and Children′s Hospital between January 2008 and February 2018. To analysis the influencing factors of PI in early-stage cervical cancer. Results: Of the 200 patients, 15 (7.5%) had PI positive, 185 (92.5%) were PI negtive. Univariate analysis showed that age, pathological type, International Federation of Gynecology and Obstetrics (FIGO) stage, histopathological grade, tumor size and margin status were uncorrelated with PI (both P＞0.05), but which was correlated with lymph-vascular space invasion (LVSI) and positive lymph nodes（both P＜0.05）. Multivariate analysis showed that LVSI positive (OR=5.456, 95%CI: 1.669-17.833, P=0.005) and lymph nodes positive (OR=6.725, 95%CI: 1.833-24.669, P=0.004) were independent risk factors of PI. Conclusions: LVSI in the cervical conization specimens and lymph nodes positive and PI are correlated. Those factors can be used as predictors of PI.

Key words: Uterine cervical neoplasmsr, Lymphatic metastasis, Neoplasm invasiveness, Factor analysis, statistical