Abstract: As the collective name for precancerous lesions of cervical cancer，cervical intraepithelial neoplasia is closely related to cervical cancer. High-risk human papillomavirus (HR-HPV) infection is the most important cause of cervical cancer and precancerous lesions. By enhancing anti-infective immunity and anti-tumor immunity，most of the women can eliminate virus and diseased cells and prevent cervical cancer. Immune cells and their secreted cytokines play an important role in this. The cytokines IL-2 and IL-10 are low-molecular-weight soluble proteins produced and secreted by immune cells stimulated by immunogens or other factors，which have high affinity with receptors and participate in cellular immunity and humoral immunity of the body. IL-2 and IL-10 play an important role in the pathogenesis and development of cervical lesions，but its specific role and mechanism in cervical cancer and precancerous lesions are still unclear and controversial. This article summarizes the related literature reports and try to illustrate the relationship between cytokines IL-2，IL-10 with HR-HPV infection as well as cervical cancer.

Key words: Uterine cervical neoplasms, Cervical intraepithelial neoplasia, Papillomaviridae, Interleukin-2, Interleukin-10