Abstract: Objective：To discuss the clinical and pathological characteristics, therapy and prognosis of clear cell adenocarcinoma of cervical(CCAC). Methods: We performed a retrospective review of 13 patients with CCAC who were diagnosed and treated at the First Affiliated Hospital of Zhengzhou University from April 2013 to December 2017. Result: The age of the patients was (53.6±13.9) years，of which 9 (69.2%) were older than 40 years and 4 (30.8%) were younger than 40 years, 2 were adolescents. The International Federation of Gynecology and Obstetrics stage: 46.15% (n=6) stage I, 46.15% (n=6) stage II, 7.7% (n=1) stage III. Twelve patients underwent surgery followed by radiotherapy and chemotherapy, including 3 patients treated by neoadjuvant chemotherapy, 9 postoperative adjuvant radiotherapy and/or chemotherapy. One patient was treated by radiotherapy alone. The median follow-up time was 24 months (6-60 months). 4 patients died and 2 patients had multiple metastases. The 1-year, 2-year and 5-year survival rates were 12/13、11/13 and 9/13, respectively. Conclusions: CCAC has low incidence, nonspecific clinical manifestations and poor prognosis with lymph node metastasis. The individualized comprehensive treatment of surgery followed by radiotherapy and chemotherapy can significantly improve the patient′s condition.

Key words: Uterine cervical neoplasms, Adenocarcinoma, clear cell, Therapy, Prognosis