Abstract: Vulva Lichen Sclerois(VLS) is a chronic refractory skin disease in women. It mainly occurs in vulval and perianal skin. It mainly occurs in Vulvar and perianal skin and is characterized by whitening and pruritus of vulvar skin. Patients with obvious vulvar pain and induration should be alert to develop Vulvar squamous-cell Carcinoma (VSCC). This article introduces a 56-year-old woman with a history of VLS for more than 40 years. Taking the material from the Labia Majoris, the histopathology showed "VLS, mild". Later the separation of vulva adhesion was performed for the adhesion of the clitoris and obvious pain, showing that the clit was dark red and cauliflower-shaped. After two biopsies with biopsy forceps and cold knife, VSCC was confirmed by histopathology, then extensive eulvectomy plus bilateral inguinal lymphadenectomy was performed. Further radiotherapy and chemotherapy were given after the operation. It is suggested that VLS with a long history of local induration and obvious pain should be alert for canceration. If the clitoris is painful and sticky, it should undergo adhesion separation, expose the clitoris, and repeat the material when necessary, so as to avoid misdiagnosis.

Key words: Vulvar lichen sclerosus, Vulvar neoplasms, Neoplasms, squamous cell, Case report