Journal of International Obstetrics and Gynecology ›› 2020, Vol. 47 ›› Issue (3): 327-331.

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Long Non-Coding RNAs in Ovarian Cancer and Their Interaction with MicroRNAs

DONG Qian, LONG Xiao-ran,  DI Wen   

  1. Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology,  State Key Laboratory of Oncogenes and Related Genes,  Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Received:2019-09-24 Revised:2020-01-06 Published:2020-06-15 Online:2020-06-23
  • Contact: DI Wen, E-mail: diwen163@163.com E-mail:diwen163@163.com

Abstract: Ovarian cancer is the leading cause of death among gynecologic malignancies. Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and terminal stage. Generally, recurrent drug-resistant tumors and metastasis reduce the efficacy of treatments, therefore more sensitive and efficient diagnostic markers and therapeutic targets need to be discovered and researched. Recently, lncRNAs have been highlighted in oncology researches, showing their potential as an emerging biomarker in the diagnosis and treatment of various human malignancies. In this review, we have summarized several studies about lncRNAs involved in ovarian cancer and analyzed their roles in the tumorigenesis and development of ovarian cancer as well as the interaction between these lncRNAs and related microRNAs in disease progression.

Key words: Ovarian neoplasms;, RNA, long noncoding;, MicroRNAs;, Carcinogenesis;, Biomarkers, tumor