Abstract: At present, chemotherapy is still one of the important means to treat malignant tumors, but the side effects brought by chemotherapy should not be underestimated. Especially for women of child-bearing age, chemotherapy seriously affects the ovarian function of them, such as the decline of ovarian reserve function, premature ovarian failure, which undoubtedly brings serious physiological and psychological trauma to them. Therefore, it is important to protect ovarian function in women of reproductive age with malignant tumors while receiving chemotherapy. At present, the clinical application of protective agents to prevent ovarian function damage caused by chemotherapy is not very extensive, and the relevant research mechanism is not very clear. This article reviews the mechanism and research status of protective agents that have been used to prevent ovarian function damage caused by chemotherapy and those with potential application value, in order to provide new ideas for preventing ovarian fertility and physiological function damage of anti-cancer women of child-bearing age.

Key words: Neoplasms；, Drug therapy, combination；, Ovary；, Recovery of function；, Ovarian protectant；, Fertility