Abstract: Pre-eclampsia is a special disease in pregnancy, which can cause multiple organ and system damage, and is a common cause of maternal and perinatal death. The pathogenesis of pre-eclampsia is not clear. At present, it is considered to be related to multiple factors, mechanisms and pathways, mainly related to inadequate recasting of uterine spiral arterioles, over activation of inflammation and immunity, damage of vascular endothelial cells and so on. Recent studies have shown that microparticles (MPs) of pre-eclampsia patients can activate neutrophils through a variety of ways, which can cause neutrophils to release a variety of proteases and inflammatory factors, form neutrophil extracellular traps, and then lead to vascular endothelial cell damage. In this paper, the mechanism of MPs induced neutrophil activation and vascular endothelial injury was reviewed.

Key words: Pre-eclampsia；, Microsomes；, Granulocytes；, Extracellular traps；, Endothelium, vascular