Abstract: Platelet rich plasma (PRP) is a platelet concentrate prepared by centrifugation of autologous or allogeneic whole blood. It contains a large number of growth factors and proteins. It has biological functions such as promoting tissue regeneration and repair, angiogenesis and so on. It has been widely used in orthopedics, ophthalmology, stomatology, dermatology and so on, with significant effect and no serious adverse reactions. At present, more and more studies have applied PRP to fertility protection. Lots of articles reported that PRP can improve endometrial receptivity, ovarian reserve function, recovery of reproductive organ structure and function after chemotherapy and ischemic injury, reproductive endocrine and sexual behavior of both men and women. But the preparation standards are not uniform. Centrifugal speed, centrifugal time, anticoagulant, activator, storage time, freezing temperature, preservative, volunteer characteristics and other factors may all affect its quality. This study discusses the research progress of PRP in fertility protection，the influencing factors of PRP quality and the safety issues in the hope of providing a reference basis for its clinical application.

Key words: Platelet-rich plasma；, Gels；, Ovarian reserve；, Fertility；, Pregnancy outcomes