Research Progress of HOXA10 and Related MiRNA in Endometriosis

doi:10.12280/gjfckx.20200904

Abstract

Abstract:

Endometriosis (EMs) is a widespread gynecological disease in the world, and its specific pathogenesis is still unclear. More and more evidence shows that EMs is an epigenetic disease, which participates in the occurrence and development of EMs through DNA methylation and microRNA (miRNA) regulation. Homologous heterobox gene A10 (HOXA10) is one of the genes targeted by DNA methylation, which not only plays an important role in the female reproductive system, but also its abnormal expression and abnormal methylation pattern are closely related to the onset and infertility of EMs. MiRNA is a highly conserved non-coding regulatory RNA composed of about 22 nucleotides, which can influence endometriosis by regulating various pathophysiological processes such as adhesion, invasion, and angiogenesis of endometrial cells, but its exact mechanism is not completely clear. In recent years, it has been found that there is a correlation between HOXA10 and miRNA expression in EMs patients, and miRNA can abnormally regulate the expression of HOXA10 and promote the occurrence and development of EMs. This article reviews the research progress of HOXA10 and related miRNA in EMs, aim to provide new ideas for elucidating the possible molecular mechanism of endometriosis and its clinical diagnosis and treatment.

Key words: Endometriosis, Epigenetics, MicroRNAs, DNA methylation, Homologous box gene A10

LI Kun-yu, TANG Xiao-han, LU Mei-song. Research Progress of HOXA10 and Related MiRNA in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 10-14.

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