Advances in Research on Misfolded Protein and Preeclampsia

doi:10.12280/gjfckx.20200692

Abstract

Abstract:

Preeclampsia is a systemic heterogeneous pregnancy complication, its specific pathogenesis is not clear, and there is still a lack of accurate and reliable prediction, diagnosis and effective treatment. It is known that misfolded proteins are the product of oxidative stress in the endoplasmic reticulum, and that misfolded proteins are associated with the occurrence and development of many human diseases. Recently, some scholars have found that there are misfolded proteins in placenta, blood and urine of preeclampsia pregnant women, and the misfolded protein in preeclampsia patients has the property of congophilia. The misfolded protein in the urine of preeclampsia patients can be detected by Congo red (CR) staining. If the test result of Congo red dot (CRD) test paper is positive, it may show preeclampsia-related symptoms within the next 14 days, and the misfolded protein may be used as a biomarker for predicting preeclampsia.

Key words: Pre-eclampsia, Protein conformation, Endoplasmic reticulum stress, Amyloid, Placenta, Forecasting, Biomarkers

WEN Ning-ning, DU Juan. Advances in Research on Misfolded Protein and Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 247-250.

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