Abstract:

Vancomycin is a glycopeptide antibiotic that inhibits bacterial growth and reproduction by inhibiting bacterial cell wall protein synthesis, changing the permeability of bacterial cell membranes and hindering bacterial RNA synthesis, thereby killing bacteria. Adverse reactions such as nephrotoxicity, red man syndrome, gastrointestinal reactions, cytopenia (leukopenia, platelets, eosinophilia, etc.), hyperpyrexia, allergic reactions may occur during the application. Differentiated adverse reactions from uncontrolled infections could avoid blind surgery and over treatment. A case of refractory drug fever, leukopenia with suspected red man syndrome after 9 days of fever withdrawal with vancomycin was misdiagnosed as an uncontrolled infection and treated surgically was reported. The aim was to raise awareness of the adverse effects of vancomycin, thereby better improve the level of diagnosis and treatment of pelvic inflammatory diseases.

Key words: Vancomycin, Pelvic infection, Drug-related side effects and adverse reactions, Fever, Leukopenia, Drug eruptions, Diagnostic errors