Research Progress of Female Genital Tract Inflammation in the Pathogenesis of Endometriosis

doi:10.12280/gjfckx.20221053

Abstract

Abstract:

Endometriosis (EMs) is a common gynecologic disease with an unclear pathogenesis. The inflammatory response can alter the uterine and abdominal microenvironment, among which the occurrence of pelvic inflammatory diseases can lead to ectopic lesions in the formation process of adhesion, invasion and angiogenesis more easily. Chronic endometritis can affect the changes of estrogen receptors in the eutopic endometrial tissue, thus leading to an increase of estrogen production, making the endometrial tissue more biologically active and easier to implant in pelvic organs after escaping pelvic immune surveillance. Female lower genital tract inflammatory diseases can infect upper genital tract, resulting in inflammation of the uterine cavity and abdominal cavity microenvironment, which plays an important role in the occurrence of EMs. At the same time, pelvic inflammatory disease, chronic endometritis and female lower genital tract inflammatory disease are also risk factors to aggravate the severity of EMs.

Key words: Inflammation, Endometriosis, Cell adhesion, Neovascularization, pathologic, Endometritis

WANG Song, ZHANG Wei, SONG Dian-rong. Research Progress of Female Genital Tract Inflammation in the Pathogenesis of Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2023, 50(3): 251-255.

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