Abstract:

Endometrial angiosarcoma is a rare interstitial sarcoma in clinic. Its clinical symptoms are atypical and diagnosis is relatively difficult. The diagnosis is mainly based on tissue biopsy. There is no standard treatment. The diagnosis and treatment of one case of endometrial angiosarcoma was reported. The patient was treated for abnormal vaginal bleeding for more than 1 month, during which the blood loss was more than the usual menstrual volume. After admission, specialized physical examination, gynecological ultrasound and pelvic magnetic resonance imaging were performed, and endometrial sarcoma was considered based on the diagnostic endometrial curettage pathological section of other hospital. Extensive hysterectomy, bilateral adnexectomy, pelvic lymphadenectomy and para-aortic lymph node biopsy were performed. Postoperative pathology showed endometrial angiosarcoma with clinical stage ⅢC1. The patient did not undergo adjuvant treatment after the operation, and was reviewed 5 months after the operation to consider recurrence and metastasis. The postoperative recurrence time of endometrial angiosarcoma is short and there is a risk of distant metastasis. Postoperative adjuvant chemoradiotherapy, immunotherapy and targeted therapy after surgery can improve the survival rate of patients.

Key words: Endometrial neoplasms, Hemangiosarcoma, Biopsy, Immunohistochemistry, Therapy