The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosi

doi:10.12280/gjfckx.20230734

Abstract

Abstract:

Endometriosis is a common disease in women of childbearing age, and its pathogenesis has not yet been clarified. The disease has unique tumor-like characteristic, and the immune microenvironment, which consists of both cellular components (e.g., macrophages, natural killer cells, and T-lymphocytes) and non-cellular components, plays an important role in the development of ectopic lesions. Spatial transcriptome technology, as a new technology to study multiple cellular interactions and cellular spatial connectivity in recent years, can not only provides an overall view of the immune microenvironment, but also be used to explore the dynamic development and spatial specificity of immune cells in the microenvironment. Therefore, spatial transcriptome technology provides a new technique and new insights for in-depth investigation of the immune microenvironment in endometriosis.

Key words: Endometriosis, Immune system, Leukocytes, mononuclear, Cytokines, Immune microenvironment, Spatial transcriptome

XU Ze-mei-hong, YANG Ru-yu, WU Qiong, LYU Yi, LIANG Yan-chun. The Potential Application of Spatial Transcriptome Technology in the Research of Immune Microenvironment of Endometriosi[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 82-86.

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