Research Progress on Glucose and Lipid Metabolism in Decidualization of Endometrial Stromal Cells in Patients with PCOS

doi:10.12280/gjfckx.20250509

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease among women of reproductive age. The imbalance of glucose and lipid metabolic homeostasis in PCOS can interfere with decidualization process of endometrial stromal cell (ESC) and significantly increase the risk of adverse pregnancy outcomes. Studies have found that in terms of glucose metabolism, there are abnormal mechanisms in patients with PCOS, such as abnormal epigenetic regulation, insulin signaling pathway transduction disorders, and the influence of hyperandrogenism on endoplasmic reticulum stress. In terms of lipid metabolism, hyperandrogenism acts on the Wilms tumor 1-very low density lipoprotein receptor (WT1-VLDLR) pathway, leading to abnormal lipid storage, and the disorder of PCOS-related adipokines inhibits ESC decidualization. This review summarizes the mechanisms of abnormal glucose and lipid metabolism during the decidualization of ESC in patients with PCOS, providing a theoretical basis for in-depth research on the metabolic factors of reproductive disorders in PCOS and the further development of treatment strategies targeting metabolic remodeling.

Key words: Polycystic ovary syndrome, Endometrium, Stromal cells, Glucose metabolism disorders, Lipid metabolism disorders, Decidualization

ZENG Hui-fang, DOU Zhen, LI Yu-xin, JIANG Xin-yu, XIA Tian. Research Progress on Glucose and Lipid Metabolism in Decidualization of Endometrial Stromal Cells in Patients with PCOS[J]. Journal of International Obstetrics and Gynecology, 2025, 52(5): 534-539.

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