Abstract:

Cushing syndrome (CS) is a rare endocrine disorder characterized by hypercortisolism. CS complicating pregnancy is even rarer. Affected by the physiological increase of cortisol levels during pregnancy, the diagnosis and management of this disease are particularly complex. A case of a pregnant patient with adrenocorticotropic hormone (ACTH)-independent CS presenting with hip pain as the first symptom is reported. The patient had obvious metabolic disorders and typical signs of CS. Laboratory tests indicated hypercortisolism, and an adrenal ultrasound revealed an adenoma in the right adrenal gland. A multidisciplinary team collaborated to develop an individualized plan. The patient underwent a cesarean section at 30⁺³ weeks of gestation, and a right adrenalectomy was performed 6 weeks after delivery. The symptoms improved significantly after the operation, and the follow-up indicated favorable outcomes for both the mother and the infant. This case suggests that if there are abnormal weight gain, metabolic disorders, or skin changes during pregnancy, the possibility of potential endocrine diseases should be alerted and evaluated as early as possible. Multidisciplinary collaboration and psychological intervention are the keys to optimizing the pregnancy outcomes of CS patients.

Key words: Cushing syndrome, Pregnancy, Diagnosis, Therapy, Pregnancy outcomes