Research Progress on the Treatment of Endometriosis with Mesenchymal Stem Cells

doi:10.12280/gjfckx.20250917

Abstract

Abstract:

Endometriosis (EMs) is a common gynecological disease. Traditional treatment methods have limitations such as high recurrence rates and damage to ovarian function. Mesenchymal stem cells (MSCs) have emerged as a novel therapeutic approach due to their multi-directional differentiation potential and immunomodulatory properties. This review summarizes the dual roles of MSCs in EMs: pathogenic MSCs drive disease progression through abnormal proliferation and fibrosis, while therapeutic MSCs exert effects through mechanisms such as immunomodulation and anti-angiogenesis. The review focuses on the progress of strategies such as stem cell transplantation, cell-free therapy, gene modification, and combination therapy, and analyzes the challenges in clinical translation, including drug delivery safety, long-term efficacy, and standardization issues. Future research should optimize the delivery system and improve the evaluation criteria to promote the clinical application of MSC therapy.

Key words: Mesenchymal stem cells, Endometriosis, Mesenchymal stem cell transplantation, Exosomes, Immunomodulation

ZHANG Xiu-xia, WU Xue-li, MA Yue, LI Hong-li, LIU Chang. Research Progress on the Treatment of Endometriosis with Mesenchymal Stem Cells[J]. Journal of International Obstetrics and Gynecology, 2026, 53(1): 53-59.

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