Abstract: Sphingosine-1-phosphate (S1P), a kind of bioactive messenger, acts via the specific cell surface G-protein-coupled receptors, S1PR1-5, to mediates various biological behaviors. Emerging evidence shows that, through S1PR1, S1PR2 and S1PR3, S1P exerts both positive and negative effects on the regulation of vascular formation, including endothelial cells movement and adhesion, vascular development, barrier protection and vascular functions. Tumor angiogenesis plays crucial roles in tumor growth. Blockade of S1P and its signaling of angiogenesis play an anti-tumor effect in breast cancer and prostate cancer. It has been proved that S1P is involved in angiogenesis of ovarian cancer but the mechanism is not clear. Further research is expected to provide new therapeutic direction to inhibit the growth of ovarian cancer.

Key words: Sphingosine, Neovascularization, pathologic, Neoplasms, Ovarian neoplasms