Abstract: Objective：To explore the application value of serum HE4 and CA125 level changes in the assessment of curative effect in ovarian cancer. Methods：HE4 and CA125 levels of 34 patients suffering from epithelial ovarian cancer （ＥＯＣ） were measured by electrochemiluminescence in one week，one month, three months and six months after surgery and compared with the corresponding values before surgery. The relevance between disease progression after surgery and the corresponding changes of HE4 and CA125 levels was compared. Results：HE4 and CA125 levels in serum of EOC patients were significantly higher than the control group（Ｐ＜０．０１）. In 27 remission cases, HE4 and CA125 values in one week, one month, three months and six months after surgery were significantly lower than before surgery（Ｐ＜０．０１）. The concentration of two markers were decreasing as the extension of time after surgery（Ｐ＜０．０１２ ５）. HE4 and CA125 levels showed statistical difference in 7 postoperative deterioration cases in one week and one month after the surgery （Ｐ＜０．０５）. Joint detection of HE4 and CA125 can elevate the coincidence rate to 85.3%. Conclusions：Simultaneous detection of HE4 and CA125 may have important value of clinical efficacy evaluation and monitoring of disease after EOC surgery.

Key words: Ovarian neoplasms, Proteins, CA-125 antigen, Tumor markers, biological