Abstract: Somatostatin（SST）is a regulatory peptide, inhibiting the release of many hormones , with a wide range of endocrine inhibitory effect on diseases such as upper gastrointestinal bleeding, acute pancreatitis and acromegaly. The FDA has recognized somatostatin analogues as Class B drugs，and the domestic and foreign clinicians often use them to treat the pregnancy-complicated diseases，but the application security of them in human pregnancy is still inconclusive and worth further studying. Progress for the application security of somatostatin analogues on mother and fetus in pregnancy.

Key words: Somatostatin analogue, Pregnancy, Mother and Fetus, Security