Abstract: Objective：To investigate whether pure serum thyroid peroxidase antibody (TPO-Ab) positive in early gestation women with euthyroidism can influence their pregnancy complications and outcomes. Methods：The clinical data of pregnant women with euthyroidism and gestational age were less than 13 weeks in our hospital was collected. All subjects were divided into two groups,on basis of TPO-Ab negative-TPO-Ab group(＜60 kU/L, 793 cases), positive-TPO-Ab group (≥60 kU/L, 88 cases). Follow up the change of thyroid function, compare the difference of pregnancy outcome in two groups. Results：The serum level of TSH in positive-TPO-Ab group was higher than negative-TPO-Ab group (t=2.079, P=0.038). The incidence rate of premature rupture of membrane, fetal growth restriction (FGR) and infant of low-birth weight in positive-TPO-Ab group were higher than negative-TPO-Ab group (7.95% vs. 1.89%, χ2=9.598, P=0.002; 2.27% vs. 0.37%, χ2=5.126, P=0.024; 5.68% vs. 2.12%, χ2=4.180, P=0.041). Conclusions：Positive-TPO-Ab was likely to have adverse effect on pregnancy complications and outcomes.

Key words: Pregn, Pregnancy complications, Pregnancy outcome, Thyroid diseases, Thyroid peroxidase antibody