Abstract: Objective：To investigate the expression of galectin-1 in peripheral blood and placental tissue of preeclampsia patients and its significance. Methods：A total of 53 cases of early onset severe preeclampsia and 53 cases of normal pregnant people were selected as research objects. The concentration of serum Gal-1 was detected by ELISA and the expression of Gal-1 protein in placenta tissue was detected by immunohistochemistry. Results：The concentration of serum Gal-1 of the observation group and the control group were （38.59±9.02） ng/L and （27.33±8.31） ng/L, respectively. There was significant differences between the two groups （t=6.684, P＜0.001）. The expression of Gal-1 protein in observation group was significantly higher than that in the control group （Z=5.632，P＜0.001）. Conclusions：Gal-1 may be related to the early onset severe preeclampsia. It may be a valuable biomarker for predicting preeclampsia.

Key words: Pre-eclampsia, Galectin 1, Blood chemical analysis, Placenta