Abstract: Ovarian cancer is one of the most common malignant tumors of the three cancers female genital organs, and its mortality rate ranks first in gynecological malignancies. The research shows that the occurrence and development of tumor resistance is related to epigenetics. The related research also confirmed that epigenetics regulated the occurrence and development of ovarian cancer and drug resistance, such as DNA methylation, histone modification and MicroRNA genes. The epigenetics such as DNA methyltransferase inhibitors or histone deacetylase inhibitors can significantly improve the curative effect of ovarian cancer. The study of epigenetics and drug resistance in ovarian cancer are expected to provide new ideas and basis for clinical treatment of ovarian cancer.

Key words: Ovarian cancer, drug resistance, epigenetic