Abstract: 【Abstract】  Objective：To study the clinical effect of reduced glutathione combined with S-adenosylmethionine (SAM) in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods：117 patients with ICP in our hospital from January 2012 to June 2015 were selected by SPSS 16.0 software to generate random number table and divided into the joint group 58 cases and control group 59 cases. The control group was treated with SAM, joint group was treated with SAM + glutathione, the therapeutic effect were compared after four weeks. Results：Before treatment, There was no significant difference in blood TBA, ALT, AST levels and pruritus severity score between the combination group and the control group before treatment (P＞0.05). The blood TBA, ALT, AST levels and pruritus severity score were significantly reduced after treatment in both group (P＜0.05). After treatment, the blood TBA, ALT, AST levels and pruritus scores of the combined group were significantly lower than the control group patients (P＜0.05). There were no differences in gestational age, fetal distress, Apgar scores and birth weight between two groups (P＞0.05). The cesarean section rate in combined group was significantly lower than the control group (P＜0.05). Conclusions：Glutathione combined SAM was more effective than single SAM in the treatment of intrahepatic cholestasis of pregnancy.

Key words: 【Keywords】 , Glutathione, S-adenosylmethionine, Pregnancy, Cholestasis, intrahepatic