Abstract: 【Abstract】  Objective：To investigate the value of serum uric acid level within 1 months before delivery on maternal-fetal pregnancy outcomes with pre-eclampsia. Methods：A retrospective study was conducted on 152 pregnant women with pre-eclampsia who had delivered in Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiaotong University from April 2014 to December 2015. According to whether complicated with severe index and the onset gestational weeks, all selected patients with pre-eclampsia were divided into severe group (n=106), non severe group (n=46), early onset group (n=75) and late onset group (n=77). Indexes of pregnant women within one month before delivery contain serum uric acid (the above indicators were selected for the most serious condition); pregnancy complications such as pleural or peritoneal effusion, liver or kidney dysfunction; perinatal health indicators such as newborn birth weight, the Apgar score and the ratio of peak systolic to least diastolic flow velocity of fetal umbilical artery (S/D). Results：The serum uric acid level in early onset or severe pre-eclampsia was significantly higher than that in late onset or mild pre-eclampsia. The Logistics regression analysis showed that elevated level of serum uric acid might be one of risk factors for adverse maternal-fetal pregnancy outcomes with pre-eclampsia. According to receiver operating characteristic curves (ROC), we found that: when the serum uric acid level was increased to 388-440 μmol/L, there was statistical significance for forecasting adverse maternal-fetal pregnancy outcomes (P＜0.01). Conclusions：The serum uric acid level has important predictive value to patients with pre-eclampsia on maternal-fetal pregnancy outcomes and the opportunity of pregnancy termination.

Key words: 【Keywords】 , Pre-eclampsia, Uric acid, Maternal-fetal relations, Pregnancy outcome, Forecasting