Abstract: Human epididymis protein 4(HE4) is a new tumor biomarker in recent years, many scholars at home and abroad have researched about it. HE4 originally found in people distal epididymal epithelial cells which have the ability to inhibit proteases and express in multiple tissue of the human body. HE4 has important value in diagnosis of ovarian cancer, especially in the early ovarian cancer which can diagnose of benign and malignant ovarian tumors, and also has superiority in monitoring recurrence. At the same time, research has shown that HE4 has a guiding significance  in diagnosis, prognosis and staging of endometrial carcinoma. In addition, HE4 can also be used for the diagnosis and monitoring of benign disease of gynecology such as endometriosis, uterine adenomyosis, etc. We has been adopting the recommended HE4 reference value of America as a diagnostic criteria for the lack of crowd HE4 reference research in China. In view of this, HE4 Chinese population reference multicenter study was officially launched in 2012. Through the study of the large sample of people in our country, it provided the reference range of HE4 levels, which will guide Chinese doctor to apply HE4 results for clinical diagnosis and treatment, effectively improve the clinical management of gynecological oncology.

Key words: Human epididymis protein 4, Tumor markers, biological, Genital neoplasms, female, Ovarian neoplasms, Endometrial neoplasms