Abstract: Metabonomics analyzes the small molecule metabolites from samples using nuclear magnetic resonance and mass spectrum analysis technology and data analysis method. It can obtain the characteristic spectrum of metabolites which is closely related to the occurrence and development of the disease. It plays an important role in disease prevention, diagnosis, treatment and prognosis. The study found that the characteristic metabolites spectrum in the maternal plasma, urine, and amniotic fluid can predict fetal abnormalities, and maternal plasma metabonomics can predict the occurrence and type of preeclampsia, and placental and umbilical cord blood metabonomics can predict intrauterine hypoxia and the growth of fetal, and vaginal metabolomics can predict the occurrence of premature. Metabonomics technology has important guiding significance for studying the diseases occurrence, development and prognosis in pregnant women and neonatte.

Key words: Metabolism, Obstetrics, Nuclear magnetic resonance, biomolecular, Mass spectrometry