New Research Progress on the Relationship between Brown Fat Tissue and Polycystic Ovary Syndrome

Abstract

Abstract: Polycystic ovarian syndrome (PCOS) is a common disorder of reproductive metabolism with high heterogeneity. Its main manifestations are obesity, insulin resistance (IR), hirsutism, infertility, late onset of cardiovascular and cerebrovascular diseases, ovarian cancer and other long-term complications. Brown adipose tissue (BAT) is the main body heat producing tissue and plays an important role in metabolism. It has been found that BAT is closely related to the formation of PCOS. On the one hand, obesity caused by metabolic disorders of BAT further accelerates the occurrence of abnormal ovulation and related complications; on the other hand, the cytokines secreted by BAT are the key to alleviate IR and reduce the inflammatory state of PCOS. Based on the study of the relationship between BAT and PCOS, we have derived the treatment methods including exogenous BAT transplantation, iris factor supplement, drug-induced adipose tissue browning and so on, so as to diversify the treatment methods of PCOS. In this paper, the research progress of BAT and its relationship with PCOS is reviewed.

Key words: Adipose tissue, brown, Polycystic ovary syndrome, Insulin resistance, Obesity, Metabolic syndrome

LI Zi-han，LI Xiu-yang，ZHANG Ning，WU Zhi-juan，ZHOU Guan-lun，LI Xiao-xia. New Research Progress on the Relationship between Brown Fat Tissue and Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2018, 45(2): 188-191.

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