Abstract: Glucose regulation protein 78 (GRP78), one member of the family of heat shock protein 70,  is not only an important molecules in cells partner, but also a specific molecular marker of endoplasmic reticulum stress, which plays an important role during the protein folding and the transfer process, to adjust the stable of intracellular environment through various channels to maintain cells survive. In recent years, the study found that GRP78 highly expressed in maternal serum and placenta nourish cells of pregnancy idiopathic disease such as preeclampsia, gestational diabetes, at the same time involved in the chronic complications such as hypertension, diabetes, which is closely related to the occurrence and development of a variety of diseases. Now carry on the analysis and summary of the GRP78 biological function and its relationship with various pregnancy-related disease, to explore whether the protein has prediction effect, to provide new way of thinking for perinatal related diseases prevention and treatment.

Key words: Pre-eclampsia, Diabetes, gestational；, Fetal distress, Glucose regulation protein 78