Abstract: Placenta accreta is one of the most serious complication of obstetrics, which can lead to serious complications such as severe bleeding, shock, uterine perforation and secondary infection in pregnant women, and endanger the life of mother and child. The incidence is increasing year by year due to the increase of uterine cavity operation and the increase of reproductive age. At present, the prenatal diagnosis of placental accreta is mainly based on the results of imaging. Although it has high sensitivity, there are still some defects in specificity. To improve the prenatal diagnosis of placenta accreta, more and more scholars at home and abroad have focused on the mechanism of placental implantation in recent years. In the stage of placenta accreta there are abnormal biological factors expression in the patients' body. On the one hand, it reflects the progress of the disease, on the other hand, it provides reference for antenatal diagnosis. This article reviews the role of abnormal expression of related factors in placental tissue and maternal blood in the occurrence of placenta accreta.

Key words: Placenta, Placenta accreta, Cytokines, Prenatal diagnosis, Review