Abstract: Objective：To explore the expression level and clinical implications of serum sTWEAK，TNF-α and IL-10 in epithelial ovarian cancer（EOC） patients. Methods：Totally 43 patients with EOC（EOC group） and benign epithelial ovarian tumor （BOT group） were selected from Renji Hospital，School of Medicine，Shanghai Jiao Tong University. These patients were admitted to the hospital during the period from January 2010 to February 2014. The levels of serum sTWEAK，TNF-α and IL-10 were detected by ELISA. Results：①Compared to the BOT group，the expression levels of sTWEAK （P＜0.05） and TNF-α（P＜0.01） were significantly increased in the EOC group，the elevation of IL-10 level was not significant （P＞0.05）. ②The expression levels of sTWEAK，TNF-α and IL-10 in peripheral serum in EOC group were not significantly different with different clinical stages，pathological types， histological grade and ascites presence of tumor cells（P＞0.05）. ③In both two groups，the expression level of sTWEAK was positively correlated with serum TNF-α（rs=0.505，P=0.001）and was no correlation with serum IL-10（rs=0.154，P=0.325）. Conclusions：Serum sTWEAK and TNF-α expression levels were closely correlated with the pathogenesis of EOC. In patients with high sTWEAK expression，the expression of TNF-α was dominant.

Key words: Ovarian neoplasms, Tumor necrosis factor-alpha, Interleukin-10, sTWEAK, Enzyme-linked immunosorbent assay