Abstract: Perfluorinated and polyfluoroalkyl substances(PFASs) are a new type of persistent organic pollutants(POPs) that are widespread in the environment and organisms and have many aspects of toxicity. Some experimental and epidemiological findings have shown that PFASs exposure is associated with ovarian cancer in women. In recent years, domestic and foreign reports on the relationship between PFASs and ovarian cancer have been increasing, among which the toxicology, epigenetics and the corresponding carcinogenic mechanism of PFASs exposure have become an important topic of discussion.This paper reviews the latest research progress on the relationship between PFASs and ovarian cancer, and discusses the existing problems and future research directions of PFASs.

Key words: Fluorine compounds, Ovarian neoplasms, Environmental exposure, Epigenesis, genetic