Abstract: Ovarian fibroma originates from the sex cord stroma. About 10%-15% of ovarian fibroma may be combined with hydrothorax or ascites, also known as Meigs syndrome. The clinical data of a case of ovarian fibroma with increased CA125 and Meigs syndrome admitted to the Obstetrics and Gynecology Department of Jilin University Second Hospital in February 2019 were retrospectively analyzed. The patient with CA125＞1 000 U/mL, which was highly suspected of ovarian malignancy, was admitted due to abdominal distension for 2 months. Postoperative pathological diagnosis was fibroma of ovarian stromal origin. After surgery, CA125 of the patient fell to the normal range and ascites disappeared. It is suggested that clinicians should consider the possibility of ovarian fibroma combined with Meigs syndrome in young patients presented with ascites, ovarian mass, and increased CA125, so as to avoid misdiagnosis as ovarian malignant tumor.

Key words: Ovarian neoplasms, Fibroma, Ascites, CA-125 antigen, Misdiagnosis