Abstract: As a fat-soluble steroid derivative, vitamin D has the physiological function of maintaining the balance of calcium and phosphorus metabolism of bone. Some studies have shown that vitamin D can promote the process of cell differentiation and apoptosis in the development of diseases of the immune system, endocrine system, cardiovascular system, some tumors and inflammation. Vitamin D mainly regulates the expression of vitamin D receptor, mediates the transcription of target genes, and realizes the biological effect of anti-tumor. In recent years, some studies have found the expression of vitamin D receptor in endometrial cancer tissues, suggesting that it may be related to the progression of endometrial cancer and may be a potential target for the treatment of endometrial cancer. Vitamin D and its analogues have been used in endocrine therapy for cancer as the mechanism of anti-tumor therapy has been further explored. The biological basis of vitamin D receptor, the anti-tumor effect of vitamin D and its application in endometrial cancer were reviewed.

Key words: Endometrial neoplasms；, Vitamin D；, Receptors, calcitriol；, Neoplastic processes