Abstract: HR-HPV infection is one of the important reasons for cervical cancer. E5, E6 and E7 are three early oncoproteins ecoded from HR-HPV, they can stimulate growth and transformation of cervical epithelial cells. Recent researches revealed that E5 could cause cancer by means of interfering the growth factor receptors, disturbing cyclins and CDKs and promoting the transformation of virus oncogenes. E6 could intervene P53 to lose its negatively adjustment function to cell proliferation, and cause cells proliferation and malignant transformation toward infinity. E7 could cause cancer mainly through intervention to remove the retinoblastoma cell proliferation function. This article is to review research progresses of carcinogenesis mechanism about the three oncoproteins.

Key words: Uterine cervical neoplasms, DNA tumor viruses, Papillomaviridae, Neoplasm proteins, Human papillomavirus 16, Human papillomavirus 18