Abstract: Ovarian cancer is one of the common gynecological malignancies. Because the early symptoms are not obvious in the course of its development, diagnosis is often in the advanced stage. Most patients have a poor prognosis and a high mortality rate. There is still a lack of reliable diagnostic markers and other diagnostic methods for early detection and screening. Therefore, it is of great significance to find biomarkers with better specificity and sensitivity for improving the prognosis of ovarian cancer patients. In recent years, the in-depth study of traditional tumor markers and the discovery of non-coding RNA have brought a breakthrough to the early diagnosis of ovarian cancer. Combined detection of serum tumor markers can improve the sensitivity and specificity of early diagnosis of ovarian cancer, which has great clinical significance. Non-coding RNA plays an important role in the occurrence and development of ovarian cancer, providing evidence for the search for new biomarkers of ovarian cancer. Biomarkers with potential for diagnosis and prediction of ovarian cancer are reviewed to provide help for early clinical diagnosis of ovarian cancer and further improve the quality of life of patients.

Key words: Ovarian neoplasms, Biomarkers, tumor, RNA, long noncoding, MicroRNAs;, Sensitivity and specificity;, Early diagnosis